The Manchester United manager reportedly branded the France international a virus following last weekends disappointing 2-2 draw at Old Trafford.
Lukaku, meanwhile, scored his first Premier League goal since September against the Saints but gave an otherwise error-strewn performance, culminating in him injuring himself by tripping over the ball.
Summer signing Diego Dalot makes his full Premier League debut but their is no place, even among the substitutes, for fellow new recruit Fred. Marcos Rojo, meanwhile, makes his first Untied appearance since the final day of last season.
Arsenal arrive at Old Trafford in confident mood following Sundays north London derby victory and make two changes to the side which thumped Spurs 4-2 at the Emirates.
Aaron Ramsey, who played a key role in the comeback win, is promoted from the substitutes bench in place of Henrikh Mkhitaryan, while Matteo Guendouzi replaces the suspended Granit Xhaka.
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