The Frenchman has enjoyed a long and fraught relationship with Manchester United since his arrival in English football 22 years ago, ruffling plenty of feathers and embracing the role of irritant and adversary.
But having announced his departure at the end of the season there was a show of respect, led by his long-term foe Ferguson.
Wenger was afforded a round of applause from the home support as he walked from tunnel to dugout, and he then posed with Ferguson as the Scot presented him with a silver vase.
Current United manager Jose Mourinho, who has also had a rocky relationship with Wenger, stepped in to shake his hand and shared a few words with his opposite number before kick-off.
An interview with Ferguson also appeared in the United review programme, in which he recalled their early tussles.
"Although the Premier League started in 1992-93, that rivalry became the highlight of the league season," Ferguson said.
"Liverpool, without question, is the biggest fixture United ever got involved in, simply because of the history of both clubs: the two most successful clubs in Britain. I love those games, they're fantastic.
"I know that now the rivalry has changed a bit, with Man City doing well, but these are the games that any Man United player would love to be involved in now: against City, Liverpool, Arsenal, Chelsea, Tottenham.
"There are some great clubs and some fantastic competition in the Premier League now, but United against Arsenal was great for the game. It made the Premier League."