Injury to first-choice goalkeeper Hugo Lloris and back-up Michel Vorm means Paulo Gazzaniga makes his first competitive start for Spurs.
Dele Alli, understood to have suffered a hamstring strain, has not been named in the squad, while Toby Alderweireld is similarly sidelined.
Mamadou Sakho, meanwhile, returns for the Eagles having missed last weekend's 2-2 draw with West Ham, and Timothy Fosu-Mensah comes in for the injured Patrick van Aanholt.
Check out the confirmed team news below.
Tottenham XI: Gazzaniga, Aurier, Sanchez, Vertonghen, Rose, Dier, Winks, Sissoko, Eriksen, Son, Kane
Subs: Trippier, Nkoudou, Llorente, Dembélé, Foyth, Davies, Whiteman
Crystal Palace XI: Speroni, Ward, Dann, Sakho, Fosu-Mensah, Loftus-Cheek, Cabaye, Milivojevic, Schlupp, Townsend, Zaha
Subs: Tomkins, Hennessey, McArthur, Souaré, Sako, Puncheon, RiedewaldLet's