Arsene Wenger has restored a host of first-team stars to the starting eleven at Manchester City, but top scorer Alexandre Lacazette is on the bench..
Sead Kolasinac passed a late fitness test, shaking off a hip injury he picked up against Swansea a week ago to make the starting eleven.
Lacazette has scored five Premier League goals this season, but will start the massive game at the Etihad on the bench.
Arsenal travel to Manchester City nine points off the pace at the top of the table and eager for a statement win.
Alexis Sanchez starts furthest foward for Arsenal with Aaron Ramsey and Mesut Ozil restored to the midfield after being rested for the Europa League match on Thursday.
City want to make it nine league wins on the pounce and have fielded a near full-strength side.
Vincent Kompany and Benjamin Mendy are the only major absentees with Pep Guardiola makes just two changes from the side that came from behind to beat Napoli in mid-week.
Fabian Delph continues at left-back while Kyle Walker and David Silva comes back into the side after being rested mid-week.
Striker Sergio Aguero is also in the side after becoming City’s all-time top goalscorer in the win over Napoli.
City XI : Ederson, Walker, Otamendi, Stones, Delph, Fernandinho, De Bruyne, Silva (c), Sterling, Sane, Aguero
Arsenal XI: Cech, Bellerin, Koscielny, Monreal, Kolasinac, Coquelin, Ramsey, Xhaka, Ozil, Iwobi, Alexis