The 18-year-old England Under-19 international was included in one of six changes to the side which drew 2-2 with CSKA Moscow in Russia on Thursday evening, with only Petr Cech, Nacho Monreal, Shkodran Mustafi, Mohamed Elneny and Alexandre Lacazette surviving.
Magpies boss Rafael Benitez named the team which has won the last three games in the hope of breaking through the 40-point mark.
Check out the confirmed line ups here!
NEWCASTLE XI: Dubravka, Yedlin, Lascelles, Lejeune, Dummett, Ritchie, Diame, Shelvey, Kenedy, Perez, Gayle.
SUBS: Clark, Murphy, Slimani, Hayden, Manquillo, Joselu, Darlow.
ARSENAL XI: Cech, Chambers, Mustafi, Holding, Monreal, Elneny, Xhaka, Iwobi, Willock, Aubameyang, Lacazette.
SUBS: Mertesacker, Ospina, Welbeck, Maitland-Niles, Kolasinac, Nelson, Nketiah.
REFEREE: Anthony Taylor (Cheshire)